The AP1000 shield building structure model is used as the object of this study

and the seismic response analysis is carried out considering soil-structure interaction（SSI）.The influence of soft rock thickness and ground surface slope on dynamic response of the containment structure is discussed.The soil-structure models with soft rock thicknessesof 25 meters

30 meters

35 meters and 40 meters and ground surface slopes of 0 degrees

3 degrees and 6 degrees are established respectively using software ABAQUS.The ground motion input is achieved in our models.On the basis of comparison analysis of the calculated floor response spectrum

a certain seismic wave amplification effect can be observed in the soft rock layer than in the hard rock layer.The increase of the soft rock layer thickness will make the peak frequency move to the low frequency direction.The inclined site has a certain amplification effect on the high frequency part of the floor response spectrum.The results in this paper have certain referentialsignificance for the construction of nuclear power plant in the soft rock area.