This paper studies the CFD numerical simulation of wind-induced loads on a large span ladder-type roof structure based on a ladder gymnasium.We analyze the pressure distribution and variation of the surface of ladder-type large span roof structure by using RNGκ-εturbulence model and compared these with the results of wind tunnel tests to provide the research basis of the wind resistance research of such a large span structure.The results show that:（1）the CFD numerical simulation techniques can be applied to the wind load analysis of actual structure;（2）the height difference of ladder-type roof has a greater impact on the roof surface pressure coefficient

and on the windward side of the roof blocks the regional average pressure coefficients are negative on smaller height difference side;and on the windward side of the roof blocks the regional average wind pressure coefficients are positive on the larger height difference side.（3）the wind loads on the roof structure are mainly suctions;（4）The wind pressure coefficient on ladder-type roof eaves is lower than the coefficient on the corner recess

and it is necessary to take preventive measures where the wind pressure coefficient is higher.